Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28438034 | 0.87 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2KDM4EHSD17B10GAA | |
| SCHEMBL7381416 | 0.87 | KDM4E (0.49) | ALDH1A1SMN1; SMN2KDM4EHSD17B10GAA | |
| SCHEMBL29676455 | 0.82 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2KDM4EHSD17B10GAA | |
| SCHEMBL3028387 | 0.82 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2KDM4EHSD17B10GAA | |
| SCHEMBL7382420 | 0.81 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2KDM4EHSD17B10GAA | |
| SCHEMBL7382246 | 0.81 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2KDM4EHSD17B10GAA | |
| SCHEMBL7376961 | 0.81 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2KDM4EHSD17B10GAA | |
| SCHEMBL7379815 | 0.81 | ADRA2A (0.45) | ALDH1A1SMN1; SMN2KDM4EHSD17B10TSHR | |
| SCHEMBL28939503 | 0.81 | MAPK1 (0.49) | ALDH1A1SMN1; SMN2KDM4EHSD17B10GAA | |
| SCHEMBL7382176 | 0.80 | TSHR (0.51) | ALDH1A1SMN1; SMN2KDM4EHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4525478-A | Certain 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylates having vasodilating and anti-hypertensive properties | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-25 | — | — | US | disclosed |
| US-4370334-A | VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| US-4338322-A | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-07-06 | — | — | US | disclosed |
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | disclosed |