Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ether SCHEMBL7386687 | 0.86 | PPARG (0.45) | PPARGRXFP1NCOR2MAPTSMN1; SMN2 | |
| SCHEMBL2881107 | 0.79 | ALDH1A1 (0.57) | PPARGRXFP1NCOR2MAPTSMN1; SMN2 | |
| SCHEMBL7368578 | 0.77 | CA1 (0.51) | PPARGRXFP1NCOR2MAPTSMN1; SMN2 | |
| SCHEMBL1647591 | 0.76 | P2RX7 (0.51) | MAPTSMN1; SMN2HPGDHTTL3MBTL1 | |
| SCHEMBL2886364 | 0.73 | ALDH1A1 (0.56) | PPARGRXFP1NCOR2MAPTSMN1; SMN2 | |
| SCHEMBL492531 | 0.73 | CYP2C19 (0.51) | SMN1; SMN2LMNAL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL7364122 | 0.72 | KMT2A (0.52) | PPARGRXFP1NCOR2MAPTSMN1; SMN2 | |
| SCHEMBL7837703 | 0.70 | ALDH1A1 (0.47) | RXFP1MAPTSMN1; SMN2LMNAHPGD | |
| SCHEMBL2679986 | 0.69 | KMT2A (0.55) | PPARGRXFP1NCOR2MAPTLMNA | |
| SCHEMBL7439343 | 0.69 | KMT2A (0.63) | PPARGRXFP1NCOR2MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714897-B1 | FUSED HETEROAROMATIC CYCLOPENTENE DERIVATIVE HAVING ENDOTHELIN-ANTAGONIST ACTIVITY | BANYU PHARMA CO LTD (JP) | 2001-02-14 | — | — | EP | disclosed |
| US-5714479-A | TREATMENT OF HYPERTENSION, ACUTE RENAL FAILURE, ANGINA PECTORIS, ARTERIOSCLEROSIS, ASTHMA, GASTRIC ULCER AND SIMILAR AILMENTS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1998-02-03 | — | — | US | disclosed |
| EP-0714897-A1 | FUSED HETEROAROMATIC CYCLOPENTENE DERIVATIVE HAVING ENDOTHELIN-ANTAGONIST ACTIVITY | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1996-06-05 | — | — | EP | disclosed |
| US-5389620-A | Bronchodilation agent, vasodilation | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1995-02-14 | — | — | US | disclosed |