Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381790 | 0.92 | ALDH1A1 (0.39) | PIK3CALMNAALDH1A1HSD17B10HPGD | |
| SCHEMBL7378299 | 0.84 | ALDH1A1 (0.35) | LMNAALDH1A1HPGDKDM4EL3MBTL1 | |
| SCHEMBL7699445 | 0.82 | HSD17B10 (0.36) | LMNAALDH1A1HSD17B10HPGDPOLB | |
| SCHEMBL7385304 | 0.81 | MAPT (0.39) | ALDH1A1HPGDPOLBKDM4EL3MBTL1 | |
| SCHEMBL7702331 | 0.81 | ALDH1A1 (0.45) | LMNAALDH1A1HSD17B10HPGDKDM4E | |
| SCHEMBL7699846 | 0.80 | TSHR (0.46) | LMNAALDH1A1HSD17B10HPGDALOX15 | |
| SCHEMBL7696668 | 0.80 | CA12 (0.48) | LMNAALDH1A1HSD17B10GAATP53 | |
| SCHEMBL7385104 | 0.79 | NOTUM (0.40) | LMNAALDH1A1POLBKDM4EL3MBTL1 | |
| SCHEMBL7385154 | 0.79 | ALDH1A1 (0.43) | LMNAALDH1A1HSD17B10HPGDALOX15 | |
| SCHEMBL7698997 | 0.79 | CYP4F2 (0.41) | ALDH1A1KMT2AGAATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998055475-A1 | GUANIDINE DERIVIATIVES AS INHIBITORS OF NA+/H+ EXCHANGE IN CELLS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-12-10 | — | — | WO | disclosed |