Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.32 |
| ▸ | PTPRC | P08575 | 1/20 | 0.31 |
| ▸ | EDNRB | P24530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5111011 | 0.79 | TP53 (0.57) | KMT2ATP53ALOX15MAPK1PTGS2 | |
| SCHEMBL27659211 | 0.79 | TP53 (0.53) | KMT2ATP53ALOX15MAPK1PTGS2 | |
| SCHEMBL1408548 | 0.76 | TP53 (0.54) | KMT2ATP53ALOX15MAPK1PTGS2 | |
| SCHEMBL901920 | 0.76 | KMT2A (0.50) | KMT2ATP53ALOX15MAPK1PTGS2 | |
| SCHEMBL1520751 | 0.75 | KMT2A (0.71) | KMT2ATP53ALOX15MAPK1ALDH1A1 | |
| SCHEMBL27942120 | 0.75 | TP53 (0.49) | KMT2ATP53ALOX15MAPK1PTGS2 | |
| SCHEMBL11248331 | 0.75 | KMT2A (0.49) | KMT2ATP53ALOX15MAPK1PTGS2 | |
| SCHEMBL27574509 | 0.73 | TP53 (0.47) | KMT2ATP53ALOX15MAPK1PTGS2 | |
| SCHEMBL6629470 | 0.72 | TP53 (0.67) | KMT2ATP53ALOX15MAPK1PTGS2 | |
| SCHEMBL519565 | 0.71 | MAPK1 (0.44) | KMT2ATP53ALOX15MAPK1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5252574-A | Hypotensive agents, vision disorder | MERCK & CO., INC. (US) | 1993-10-12 | — | — | US | disclosed |
| US-5198438-A | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED THIOPHENE OR FURAN | MERCK & CO., INC. (US) | 1993-03-30 | — | — | US | disclosed |
| US-5177074-A | Heterocyclic nitrogen compounds used to treat hypertension, cognitive dysfunction, anxiety or depression | MERCK & CO., INC. (US) | 1993-01-05 | — | — | US | disclosed |
| EP-0513979-A1 | Angiotensin II antagonists incorporating a substituted thiophene or furan | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| EP-0512675-A1 | Angiotensin II antagonists incorporating a substituted thiophene or furan | MERCK & CO. INC. (US) | 1992-11-11 | — | — | EP | disclosed |
| EP-0510812-A1 | Angiotensin II antagonists incorporating a substituted thiophene or furan | MERCK & CO. INC. (US) | 1992-10-28 | — | — | EP | disclosed |