Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.82 |
| ▸ | PKM | P14618 | 2/20 | 0.67 |
| ▸ | TCF4 | P15884 | 1/20 | 0.67 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.61 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.61 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | PGR | P06401 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8711296 | 0.88 | CYP19A1 (0.88) | CYP19A1PKMTCF4CTNNB1ALDH1A1 | |
| SCHEMBL27180756 | 0.87 | TCF4 (0.69) | CYP19A1PKMTCF4CTNNB1ALDH1A1 | |
| SCHEMBL30926654 | 0.87 | TCF4 (0.69) | CYP19A1PKMTCF4CTNNB1ALDH1A1 | |
| SCHEMBL3701951 | 0.85 | CA12 (0.71) | CYP19A1TCF4CTNNB1ALDH1A1LMNA | |
| SCHEMBL31681327 | 0.85 | SMN1; SMN2 (0.65) | CYP19A1PKMTCF4CTNNB1ALDH1A1 | |
| SCHEMBL28661171 | 0.85 | CYP19A1 (0.72) | CYP19A1PKMTCF4CTNNB1ALDH1A1 | |
| SCHEMBL15054455 | 0.84 | CYP19A1 (0.80) | CYP19A1PKMTCF4CTNNB1ALDH1A1 | |
| SCHEMBL6296943 | 0.84 | CYP19A1 (0.80) | CYP19A1PKMTCF4CTNNB1ALDH1A1 | |
| SCHEMBL31681329 | 0.83 | FFAR4 (0.65) | CYP19A1TCF4CTNNB1ALDH1A1LMNA | |
| SCHEMBL23057261 | 0.83 | IDO1 (0.72) | CYP19A1PKMTCF4CTNNB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003751-A1 | HYDROXAMIC ACID SUBSTITUTED FUSED HETEROCYCLIC METALLOPROTEINASE INHIBITORS | AMGEN INC. (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999006410-A1 | HYDROXAMIC ACID SUBSTITUTED FUSED HETEROCYCLIC METALLOPROTEINASE INHIBITORS | AMGEN INC. (US) | 1999-02-11 | — | — | WO | disclosed |