Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT1 | P30419 | 3/20 | 0.34 |
| ▸ | DPP4 | P27487 | 6/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | CCR4 | P51679 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741102 | 1.00 | NMT1 (0.34) | NMT1DPP4DPP7DPP8DPP9 | |
| SCHEMBL741570 | 0.95 | DPP4 (0.33) | NMT1DPP4DPP7DPP8DPP9 | |
| SCHEMBL741571 | 0.95 | DPP4 (0.33) | NMT1DPP4DPP7DPP8DPP9 | |
| SCHEMBL738853 | 0.93 | DPP4 (0.33) | NMT1DPP4DPP7DPP8DPP9 | |
| SCHEMBL738801 | 0.93 | DPP4 (0.33) | NMT1DPP4DPP7DPP8DPP9 | |
| SCHEMBL739453 | 0.93 | MAP3K12 (0.34) | NMT1DPP4HRH1CYP2D6MAP3K12 | |
| SCHEMBL739451 | 0.93 | MAP3K12 (0.34) | NMT1DPP4HRH1CYP2D6MAP3K12 | |
| SCHEMBL739266 | 0.89 | HRH1 (0.42) | HRH1CYP2D6KCNH2 | |
| SCHEMBL739267 | 0.89 | HRH1 (0.42) | HRH1CYP2D6KCNH2 | |
| SCHEMBL742197 | 0.87 | CPB1 (0.33) | DPP4HRH1CYP2D6MAP3K12BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |