SCHEMBL7387142

SCHEMBL7387142

O=C(Nc1ccsc1)c1c[nH]c2c1C(=O)CCC2

nearest known ligand 0.37

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RORC P51449 1/20 0.37
MAPK14 Q16539 3/20 0.36
ROCK2 O75116 1/20 0.36
ROCK1 Q13464 1/20 0.36
BUB1 O43683 6/20 0.35
HPGD P15428 1/20 0.34
NAMPT P43490 1/20 0.34
CFTR P13569 1/20 0.33
IRAK4 Q9NWZ3 1/20 0.32
KDM4E B2RXH2 1/20 0.32
CASP1 P29466 1/20 0.32
HSD17B10 Q99714 1/20 0.32
AURKA O14965 1/20 0.32
AURKB Q96GD4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4897236 0.83 CFTR (0.49) ROCK2ROCK1BUB1HPGDCFTR
SCHEMBL7364883 0.82 LMNA (0.46) ROCK2ROCK1NAMPTCFTRKDM4E
SCHEMBL7367371 0.81 NTRK3 (0.42) ROCK2ROCK1NAMPTCFTRKDM4E
SCHEMBL7397423 0.81 NPC1 (0.44) ROCK2ROCK1KDM4EHSD17B10
SCHEMBL7384705 0.81 BUB1 (0.43) ROCK2ROCK1BUB1NAMPTKDM4E
SCHEMBL7364057 0.81 MAPT (0.43) ROCK2ROCK1
SCHEMBL7397449 0.81 MAPT (0.47) ROCK2ROCK1BUB1KDM4EAURKA
SCHEMBL7366047 0.81 ROCK2 (0.42) ROCK2ROCK1HPGDNAMPTCFTR
SCHEMBL7360138 0.81 LMNA (0.43) ROCK2ROCK1BUB1HPGDKDM4E
SCHEMBL7360053 0.81 CFTR (0.49) MAPK14ROCK2ROCK1BUB1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998002433-A1 CERTAIN FUSED PYRROLECARBOXAMIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 1998-01-22 WO claimed
US-6096887-A USEFUL IN THE DIAGNOSIS AND TREATMENT OF ANXIETY, SLEEP AND SEIZURE DISORDERS, OVERDOSE WITH BENZODIAZEPINE DRUGS AND FOR ENHANCEMENT OF MEMORY. NEUROGEN CORPORATION (US) 2000-08-01 US disclosed
US-5723462-A SLEEP AND SEIZURE DISORDERS; COGNITION ACTIVATORS, ANXIOLYTIC AGENTS NEUROGEN CORPORATION (US) 1998-03-03 US disclosed
WO-1998002433-A1 CERTAIN FUSED PYRROLECARBOXAMIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 1998-01-22 WO disclosed