SCHEMBL7387302

SCHEMBL7387302

CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C#N)cc1

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 3/20 0.65
AGTR2 P50052 3/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8872834 0.92 AGTR1 (0.66) AGTR1AGTR2
SCHEMBL8872761 0.90 AGTR1 (0.67) AGTR1AGTR2
SCHEMBL21083745 0.90 AGTR1 (0.58) AGTR1AGTR2
SCHEMBL24999131 0.89 AGTR2 (0.56) AGTR1AGTR2
SCHEMBL21083614 0.88 AGTR2 (0.55) AGTR1AGTR2
SCHEMBL21083709 0.87 AGTR2 (0.54) AGTR1AGTR2
SCHEMBL21083990 0.87 AGTR2 (0.54) AGTR1AGTR2
SCHEMBL21083542 0.87 AGTR2 (0.54) AGTR1AGTR2
SCHEMBL21083998 0.87 AGTR2 (0.54) AGTR1AGTR2
SCHEMBL21083594 0.86 AGTR2 (0.54) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5700938-A Intermediates for imidazopyridine derivatives EISAI CO., LTD. (JP) 1997-12-23 US disclosed
US-5618969-A Intermediates for imidazopyridines EISAI CO., LTD. (JP) 1997-04-08 US disclosed
US-5608068-A Process for the preparation of imidazopyridine derivatives and intermediates EISAI CO., LTD. (JP) 1997-03-04 US disclosed
US-5587504-A Sulfonyloxy-biphenylcarboxylic ester derivatives which are intermediates EISAI CO., LTD. (JP) 1996-12-24 US disclosed
US-5583229-A Process for the preparation of imidazopyridine derivatives EISAI CO., LTD. (JP) 1996-12-10 US disclosed
US-5559236-A Intermediates for substituted biphenylmethylmidazopyridine angiotensin II antagonists EISAI CO., LTD. (JP) 1996-09-24 US disclosed
US-5557002-A Process for the preparation of biphenyl containing intermediates useful in making angiotensin II receptor antagonists EISAI CO., LTD. (JP) 1996-09-17 US disclosed
US-5554757-A Process for the preparation of imidazopyridine derivatives, and intermediates therefore EISAI CO., LTD. (JP) 1996-09-10 US disclosed
US-5412097-A Heterocyclic compounds bearing acidic functional groups as angiotensin II antagonists MERCK & CO., INC. (US) 1995-05-02 US disclosed
EP-0627433-A1 PROCESS FOR PRODUCING IMIDAZOPYRIDINE DERIVATIVE AND INTERMEDIATE Eisai Co., Ltd. (JP) 1994-12-07 EP disclosed
EP-0503838-A2 Heterocyclic compounds bearing acidic functional groups as angiotensin II antagonists MERCK & CO. INC. (US) 1992-09-16 EP disclosed