Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | NQO2 | P16083 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL73875 | 1.00 | AHR (0.53) | AHRCYP1A2PTGS1FBP1NQO2 | |
| SCHEMBL11443780 | 0.85 | CYP1A2 (0.55) | AHRCYP1A2PTGS1FBP1NQO2 | |
| SCHEMBL22931544 | 0.79 | AHR (0.68) | AHRCYP1A2PTGS1FBP1NQO2 | |
| SCHEMBL13790263 | 0.79 | AHR (0.68) | AHRCYP1A2PTGS1FBP1NQO2 | |
| SCHEMBL13790273 | 0.79 | AHR (0.68) | AHRCYP1A2PTGS1FBP1NQO2 | |
| SCHEMBL256696 | 0.79 | CYP1A2 (0.50) | AHRCYP1A2PTGS1FBP1NQO2 | |
| SCHEMBL80465 | 0.79 | CYP1A2 (0.55) | AHRCYP1A2PTGS1FBP1NQO2 | |
| SCHEMBL1689696 | 0.79 | CYP1A2 (0.50) | AHRCYP1A2PTGS1FBP1NQO2 | |
| SCHEMBL1044870 | 0.79 | CYP1A2 (0.50) | AHRCYP1A2PTGS1FBP1NQO2 | |
| SCHEMBL1044871 | 0.79 | CYP1A2 (0.50) | AHRCYP1A2PTGS1FBP1NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045422-B2 | Piperidine derivatives with pesticidal properties | SYNGENTA PARTICIPATIONS AG (CH) | 2015-06-02 | — | — | US | disclosed |
| US-8796274-B2 | Piperazine derivatives and their use in controlling pests | SYNGENTA CROP PROTECTION LLC (US) | 2014-08-05 | — | — | US | disclosed |
| EP-1755396-B1 | PIPERAZIN DERIVATIVES AND THEIR USE IN CONTROLLING PESTS | SYNGENTA PARTICIPATIONS AG (CH) | 2014-06-18 | — | — | EP | disclosed |
| US-20130310399-A1 | CHEMICAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2013-11-21 | — | — | US | disclosed |
| US-8546569-B2 | Chemical compounds | SYNGENTA CROP PROTECTION, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| CN-103214460-A | Chemical compounds | SYNGENTA PARTICIPATIONS AG | 2013-07-24 | — | — | CN | disclosed |
| EP-1763302-B1 | CHEMICAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2013-03-06 | — | — | EP | disclosed |
| US-20120270885-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2012-10-25 | — | — | US | disclosed |
| US-8129534-B2 | Chemical compounds | SYNGENTA CROP PROTECTION, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| US-20110003991-A1 | PIPERAZINE DERIVATIVES AND THEIR USE IN CONTROLLING PESTS | SYNGENTA CROP PROTECTION, INC. (US) | 2011-01-06 | — | — | US | disclosed |
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |
| CN-1194978-A | Benzyloxy-substituted, fused N heterocycles, process for their preparation and their use as bradykinin receptor antagonists | HOECHST AG (DE) | 1998-10-07 | — | — | CN | disclosed |
| EP-0793674-A1 | HUMAN NEUTROPHIL ELASTASE INHIBITORS | CORTECH, INC. (US) | 1997-09-10 | — | — | EP | disclosed |
| US-5618792-A | USEFUL FOR TREATING ACUTE RESPIRATORY DISEASES, AND MYOCARDIAL ISHCEMIA-REPERFUSION INJURY | CORTECH, INC. (US) | 1997-04-08 | — | — | US | disclosed |
| WO-1996016080-A1 | HUMAN NEUTROPHIL ELASTASE INHIBITORS | CORTECH, INC. (US) | 1996-05-30 | — | — | WO | disclosed |
| CN-1029962-C | Triazole derivatives, their preparation and their use as fungicides | SANKYO CO (JP) | 1995-10-11 | — | — | CN | disclosed |
| CN-1058207-A | New piperidine compounds and preparation method thereof | NOVO NORDISK AS (DK) | 1992-01-29 | — | — | CN | disclosed |
| CN-1036759-A | Triazole derivative, its preparation method and its purposes as mycocide | SANKYO CO (JP) | 1989-11-01 | — | — | CN | disclosed |
| US-4874861-A | Pyridazinone derivatives, preparation thereof, and insecticidal, acaricidal, nematicidal, fungicidal compositions | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1989-10-17 | — | — | US | disclosed |
| EP-0183212-A2 | Pyridazinone derivatives, preparation thereof, and insecticidal, acaricidal, nematicidal, fungicidal compositions | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1986-06-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270885-A1 | CHEMICAL COMPOUNDS | H1-0, CHRM1, MRM1 | AHR 404/4885CYP1A2 593/4885PTGS1 1857/4885 |
| US-20110003991-A1 | PIPERAZINE DERIVATIVES AND THEIR USE IN CONTROLLING PESTS | CHRM1, CHRM5, PRMT5 | AHR 46/4885CYP1A2 432/4885PTGS1 1202/4885 |
| US-20130310399-A1 | CHEMICAL COMPOUNDS | ACHE, CHRM1, CHRM2 | AHR 529/4885CYP1A2 383/4885PTGS1 1876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.