SCHEMBL7387804

SCHEMBL7387804

O=CC(c1ccccc1)n1ccnc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 6/20 0.61
CYP17A1 P05093 9/20 0.59
MEN1 O00255 1/20 0.53
NR1I2 O75469 1/20 0.53
USP2 O75604 1/20 0.53
ABCB11 O95342 1/20 0.53
ALDH1A1 P00352 1/20 0.53
PLA2G1B P04054 1/20 0.53
TP53 P04637 1/20 0.53
PGR P06401 1/20 0.53
HSP90AA1 P07900 1/20 0.53
CYP3A4 P08684 1/20 0.53
MAPT P10636 1/20 0.53
IDO1 P14902 1/20 0.53
HPGD P15428 1/20 0.53
MAOA P21397 1/20 0.53
CNR1 P21554 1/20 0.53
HTR2A P28223 1/20 0.53
MAPK1 P28482 1/20 0.53
ADRA1A P35348 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11287252 0.91 CYP17A1 (0.74) CYP19A1CYP17A1MEN1NR1I2USP2
SCHEMBL5382493 0.85 CYP19A1 (0.47) CYP19A1CYP17A1MEN1NR1I2USP2
SCHEMBL11242107 0.83 CYP19A1 (0.63) CYP19A1CYP17A1MEN1CYP3A4ADRA1A
SCHEMBL1267769 0.83 CYP17A1 (0.82) CYP19A1CYP17A1MEN1NR1I2USP2
SCHEMBL11436593 0.82 CYP26A1 (0.52) CYP19A1CYP17A1MEN1NR1I2USP2
Bromide SCHEMBL28938866 0.81 CYP17A1 (0.80) CYP19A1CYP17A1MEN1NR1I2USP2
Hydrochloric Acid SCHEMBL28285792 0.81 CYP17A1 (0.80) CYP19A1CYP17A1MEN1NR1I2USP2
SCHEMBL11245762 0.80 CYP19A1 (0.66) CYP19A1CYP17A1CYP3A4CYP11B1CYP11B2
SCHEMBL9490860 0.80 CYP19A1 (0.66) CYP19A1CYP17A1MEN1KMT2ACYP26A1
SCHEMBL11275821 0.79 CYP17A1 (0.51) CYP19A1CYP17A1MEN1NR1I2USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6060491-A ANTICOAGULANTS; THROMBOEMBOLIC DISORDERS; PROPHYLAXIS DUPONT PHARMACEUTICALS (US) 2000-05-09 US disclosed
EP-0993448-A1 (AMIDINO)6-MEMBERED AROMATICS AS FACTOR Xa INHIBITORS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 2000-04-19 EP disclosed
US-5998424-A ANTICOAGULANTS DUPONT PHARMACEUTICALS COMPANY (US) 1999-12-07 US disclosed
WO-1998057934-A1 (AMIDINO)6-MEMBERED AROMATICS AS FACTOR Xa INHIBITORS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1998-12-23 WO disclosed