Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.78 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.65 |
| ▸ | CSNK1D | P48730 | 6/20 | 0.65 |
| ▸ | CSNK1E | P49674 | 5/20 | 0.65 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.62 |
| ▸ | GCGR | P47871 | 8/20 | 0.62 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.62 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | CSNK1A1L | Q8N752 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.57 |
| ▸ | FRK | P42685 | 2/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.57 |
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.57 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6924127 | 0.88 | ALOX5 (1.00) | ALOX5MAPK14CSNK1DCSNK1EMAPK11 | |
| SCHEMBL178158 | 0.82 | MAPK11 (0.77) | ALOX5MAPK14CSNK1DCSNK1EMAPK11 | |
| SCHEMBL7243804 | 0.80 | ALOX5 (0.79) | ALOX5MAPK14CSNK1DCSNK1EMAPK11 | |
| SCHEMBL17002223 | 0.79 | MAPK14 (0.77) | ALOX5MAPK14CSNK1DCSNK1EMAPK11 | |
| SCHEMBL30197605 | 0.79 | MAPK14 (1.00) | ALOX5MAPK14CSNK1DCSNK1EMAPK11 | |
| SCHEMBL17002317 | 0.79 | MAPK14 (1.00) | ALOX5MAPK14CSNK1DCSNK1EMAPK11 | |
| SCHEMBL6449484 | 0.78 | MAPK14 (0.73) | ALOX5MAPK14CSNK1DCSNK1EMAPK11 | |
| SCHEMBL6003680 | 0.77 | MAPK14 (1.00) | ALOX5MAPK14CSNK1DCSNK1EMAPK11 | |
| SCHEMBL17002225 | 0.77 | MAPK14 (0.77) | ALOX5MAPK14CSNK1DCSNK1EMAPK11 | |
| SCHEMBL4563107 | 0.77 | ALOX5 (1.00) | ALOX5MAPK14CSNK1DCSNK1EMAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708768-A4 | TRI-SUBSTITUTED IMIDAZOLES HAVING MULTIPLE THERAPEUTIC PROPERTIES | SMITHKLINE BEECHAM CORP (US) | 1996-08-21 | — | — | EP | disclosed |
| EP-0708768-A1 | TRI-SUBSTITUTED IMIDAZOLES HAVING MULTIPLE THERAPEUTIC PROPERTIES | SMITHKLINE BEECHAM CORPORATION (US) | 1996-05-01 | — | — | EP | disclosed |
| WO-1995003297-A1 | IMIDAZOLES FOR TREATING CYTOKINE MEDIATED DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-02 | — | — | WO | disclosed |
| WO-1995002591-A1 | TRI-SUBSTITUTED IMIDAZOLES HAVING MULTIPLE THERAPEUTIC PROPERTIES | SMITHKLINE BEECHAM CORPORATION (US) | 1995-01-26 | — | — | WO | disclosed |