Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8155039 | 1.00 | MEN1 (0.46) | MEN1KMT2APKMNPSR1ALDH1A1 | |
| SCHEMBL8155057 | 1.00 | MEN1 (0.46) | MEN1KMT2APKMNPSR1ALDH1A1 | |
| SCHEMBL7388207 | 1.00 | MEN1 (0.46) | MEN1KMT2APKMNPSR1ALDH1A1 | |
| SCHEMBL7388203 | 1.00 | MEN1 (0.46) | MEN1KMT2APKMNPSR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8123884 | 0.81 | SLC6A2 (0.46) | MEN1KMT2APKMNPSR1ALDH1A1 | |
| SCHEMBL7380081 | 0.79 | MEN1 (0.46) | MEN1KMT2APKMNPSR1ALDH1A1 | |
| SCHEMBL31080907 | 0.79 | MEN1 (0.47) | MEN1KMT2APKMNPSR1ALDH1A1 | |
| SCHEMBL31080922 | 0.79 | MEN1 (0.47) | MEN1KMT2APKMNPSR1ALDH1A1 | |
| SCHEMBL12987490 | 0.78 | MEN1 (0.45) | MEN1KMT2APKMNPSR1ALDH1A1 | |
| SCHEMBL24325946 | 0.78 | ALDH1A1 (0.36) | MEN1KMT2ANPSR1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040099-A1 | AZEPINE OR LARGER MEDIUM RING DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | Amgen Inc., (US) | 2000-10-04 | — | — | EP | disclosed |
| US-6107291-A | ANTIINFLAMMATORY AGENT | AMGEN INC. (US) | 2000-08-22 | — | — | US | disclosed |
| WO-1999032451-A1 | AZEPINE OR LARGER MEDIUM RING DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AMGEN INC. (US) | 1999-07-01 | — | — | WO | disclosed |