Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PPID | Q08752 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7388207 | 0.78 | MEN1 (0.46) | MEN1KMT2APKMNPSR1CYP1A2 | |
| SCHEMBL7388199 | 0.78 | MEN1 (0.46) | MEN1KMT2APKMNPSR1CYP1A2 | |
| SCHEMBL7388203 | 0.78 | MEN1 (0.46) | MEN1KMT2APKMNPSR1CYP1A2 | |
| SCHEMBL8155057 | 0.78 | MEN1 (0.46) | MEN1KMT2APKMNPSR1CYP1A2 | |
| SCHEMBL8155039 | 0.78 | MEN1 (0.46) | MEN1KMT2APKMNPSR1CYP1A2 | |
| SCHEMBL12987744 | 0.75 | LMNA (0.36) | MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL10372905 | 0.68 | MEN1 (0.62) | MEN1KMT2ASMN1; SMN2CYP2D6CYP2C19 | |
| SCHEMBL7453285 | 0.68 | CREBBP (0.46) | MEN1KMT2ATP53HTR2CALDH1A1 | |
| SCHEMBL7506825 | 0.68 | CREBBP (0.46) | MEN1KMT2ATP53HTR2CALDH1A1 | |
| SCHEMBL7453292 | 0.68 | CREBBP (0.46) | MEN1KMT2ATP53HTR2CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2694472-A2 | SULFONAMIDE DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2014-02-12 | — | — | EP | disclosed |
| WO-2012137982-A9 | SULFONAMIDE DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-14 | — | — | WO | disclosed |
| WO-2012137982-A2 | SULFONAMIDE DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-10-11 | — | — | WO | disclosed |