Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.51 |
| ▸ | CTSD | P07339 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | BMP1 | P13497 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7389853 | 0.87 | REN (0.58) | RENCTSDLMNAALDH1A1L3MBTL1 | |
| SCHEMBL7390896 | 0.85 | REN (0.66) | RENCTSD | |
| SCHEMBL7391664 | 0.85 | REN (0.66) | RENCTSD | |
| SCHEMBL7391896 | 0.85 | REN (0.66) | RENCTSD | |
| SCHEMBL7386105 | 0.84 | REN (0.55) | RENCTSDLMNAALDH1A1L3MBTL1 | |
| SCHEMBL7390440 | 0.82 | REN (0.73) | RENCTSD | |
| SCHEMBL7390443 | 0.82 | REN (0.73) | RENCTSD | |
| SCHEMBL7290440 | 0.80 | REN (0.52) | RENCTSDLMNAALDH1A1MMP2 | |
| SCHEMBL7392956 | 0.80 | REN (0.62) | RENCTSD | |
| SCHEMBL7390160 | 0.79 | REN (0.60) | RENCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589445-B1 | Renin Inhibiting N-(2-Amino-2-oxoethyl)Butanediamide Derivatives | BIO MEGA BOEHRINGER INGELHEIM (CA) | 1997-01-15 | — | — | EP | claimed |
| WO-1994007846-A1 | RENIN INHIBITING N-(2-AMINO-2-OXOETHYL)BUTANEDIAMIDE DERIVATIVES | BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) | 1994-04-14 | — | — | WO | claimed |