Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CCR6 | P51684 | 2/20 | 0.44 |
| ▸ | GALR2 | O43603 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1313734 | 0.96 | MAPT (0.53) | MAPTL3MBTL1POLBSMN1; SMN2NPC1 | |
| Nitric Acid SCHEMBL7392245 | 0.89 | MAPT (0.46) | MAPTL3MBTL1POLBSMN1; SMN2NPC1 | |
| SCHEMBL7246181 | 0.87 | MAPT (0.50) | MAPTL3MBTL1POLBSMN1; SMN2NPC1 | |
| SCHEMBL28403320 | 0.85 | OPRK1 (0.47) | MAPTL3MBTL1POLBSMN1; SMN2NPC1 | |
| SCHEMBL6442334 | 0.85 | MAPT (0.48) | MAPTL3MBTL1POLBSMN1; SMN2NPC1 | |
| SCHEMBL2332293 | 0.82 | MAPT (0.55) | MAPTPOLBSMN1; SMN2NPC1KDM4E | |
| SCHEMBL12113212 | 0.82 | L3MBTL1 (0.45) | MAPTL3MBTL1POLBSMN1; SMN2NPC1 | |
| SCHEMBL3586448 | 0.82 | AKR1B1 (0.47) | MAPTL3MBTL1POLBKDM4EKMT2A | |
| SCHEMBL8321809 | 0.81 | MAPT (0.54) | MAPTPOLBSMN1; SMN2NPC1KDM4E | |
| SCHEMBL6772078 | 0.81 | MAPT (0.46) | MAPTL3MBTL1POLBSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073658-A1 | PYRAZOLOPYRIMIDINONE CGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER INC. (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999054333-A1 | PYRAZOLOPYRIMIDINONE CGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER INC. (US) | 1999-10-28 | — | — | WO | disclosed |