SCHEMBL7388404

SCHEMBL7388404

CCOC(=O)C(=CC1CCc2cc(C#N)ccc2C1)c1ccc(O[C@H]2CCN(C(=O)OC(C)(C)C)C2)cc1

nearest known ligand 0.51

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 9/20 0.51
ALK Q9UM73 1/20 0.43
CHEK2 O96017 2/20 0.39
USP30 Q70CQ3 1/20 0.38
F10 P00742 2/20 0.37
PLG P00747 2/20 0.37
PRSS1 P07477 2/20 0.37
PRSS2 P07478 2/20 0.37
PRSS3 P35030 2/20 0.37
BTK Q06187 1/20 0.37
CETP P11597 1/20 0.36
F2 P00734 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7388406 1.00 GPR119 (0.51) GPR119ALKCHEK2USP30F10
SCHEMBL7388401 1.00 GPR119 (0.51) GPR119ALKCHEK2USP30F10
SCHEMBL7388215 0.82 GPR119 (0.51) GPR119ALKCHEK2USP30BTK
SCHEMBL7388213 0.82 GPR119 (0.51) GPR119ALKCHEK2USP30BTK
SCHEMBL7388747 0.81 GPR119 (0.51) GPR119ALKUSP30F10PLG
SCHEMBL7387571 0.81 GPR119 (0.50) GPR119ALKCHEK2F10BTK
SCHEMBL7390133 0.81 GPR119 (0.50) GPR119ALKCHEK2USP30BTK
SCHEMBL7390135 0.81 GPR119 (0.50) GPR119ALKCHEK2USP30BTK
SCHEMBL7387569 0.81 GPR119 (0.50) GPR119ALKCHEK2F10BTK
SCHEMBL7380746 0.80 GPR119 (0.49) GPR119ALKCHEK2CETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5962695-A ANTICOAGULANT DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1999-10-05 US disclosed
US-5866577-A AN ANTICOAGULANT AGENT DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1999-02-02 US disclosed
US-5620991-A ANTICOAGULANTS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1997-04-15 US disclosed
US-5576343-A ANTICOAGULANTS; BLOOD-COAGULATION FACTOR X INHIBITORS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1996-11-19 US disclosed
EP-0540051-B1 Aromatic amidine derivatives and salts thereof DAIICHI SEIYAKU CO (JP) 1996-04-03 EP disclosed
EP-0540051-A1 Aromatic amidine derivatives and salts thereof DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1993-05-05 EP disclosed