Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL736561 | 0.87 | GPR119 (0.43) | GPR119HRH3NPBWR1MCHR1 | |
| SCHEMBL736539 | 0.87 | GPR119 (0.42) | GPR119HRH3NPBWR1MCHR1 | |
| SCHEMBL738670 | 0.86 | GPR119 (0.49) | GPR119HRH3NPBWR1MCHR1 | |
| SCHEMBL17325169 | 0.85 | SIGMAR1 (0.56) | GPR119OPRM1SIGMAR1USP30 | |
| SCHEMBL735848 | 0.81 | HRH3 (0.50) | HRH3OPRM1SIGMAR1 | |
| SCHEMBL737490 | 0.77 | SIGMAR1 (0.58) | OPRM1SIGMAR1 | |
| SCHEMBL5239182 | 0.77 | GPR119 (0.63) | GPR119 | |
| SCHEMBL23410150 | 0.76 | GPR119 (0.61) | GPR119USP30 | |
| SCHEMBL738185 | 0.75 | HRH3 (0.47) | HRH3 | |
| SCHEMBL5268593 | 0.74 | GPR119 (0.65) | GPR119KDM1AUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138206-B2 | Piperidine derivative | MSD. K.K. (JP) | 2012-03-20 | — | — | US | disclosed |
| US-20090137576-A1 | Novel Piperidine Derivative | MSD K.K. (JP) | 2009-05-28 | — | — | US | disclosed |
| EP-1892241-A1 | NOVEL PIPERIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-02-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137576-A1 | Novel Piperidine Derivative | HRH4, HRH3, HRH1 | GPR119 314/4885HRH3 2/4885OPRM1 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.