Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 15/20 | 0.59 |
| ▸ | MMP3 | P08254 | 12/20 | 0.59 |
| ▸ | MMP13 | P45452 | 9/20 | 0.59 |
| ▸ | MMP7 | P09237 | 7/20 | 0.59 |
| ▸ | MMP9 | P14780 | 14/20 | 0.54 |
| ▸ | MMP2 | P08253 | 7/20 | 0.54 |
| ▸ | MMP8 | P22894 | 3/20 | 0.51 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.51 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381450 | 1.00 | MMP1 (0.59) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL7388766 | 1.00 | MMP1 (0.59) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL7381446 | 1.00 | MMP1 (0.59) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL7378813 | 0.94 | MMP1 (0.63) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL7386604 | 0.94 | MMP1 (0.63) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL7386603 | 0.94 | MMP1 (0.63) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL7378815 | 0.94 | MMP1 (0.63) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL7387818 | 0.92 | MMP1 (0.60) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL8153443 | 0.85 | FKBP1A (0.55) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL7385275 | 0.85 | FKBP1A (0.55) | MMP1MMP3MMP13MMP7MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040099-A1 | AZEPINE OR LARGER MEDIUM RING DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | Amgen Inc., (US) | 2000-10-04 | — | — | EP | claimed |
| US-6107291-A | ANTIINFLAMMATORY AGENT | AMGEN INC. (US) | 2000-08-22 | — | — | US | claimed |
| WO-1999032451-A1 | AZEPINE OR LARGER MEDIUM RING DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AMGEN INC. (US) | 1999-07-01 | — | — | WO | claimed |
| EP-1040099-A1 | AZEPINE OR LARGER MEDIUM RING DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | Amgen Inc., (US) | 2000-10-04 | — | — | EP | disclosed |
| US-6107291-A | ANTIINFLAMMATORY AGENT | AMGEN INC. (US) | 2000-08-22 | — | — | US | disclosed |
| WO-1999032451-A1 | AZEPINE OR LARGER MEDIUM RING DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AMGEN INC. (US) | 1999-07-01 | — | — | WO | disclosed |