Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8356012 | 0.90 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7387771 | 0.86 | PDE4A (0.54) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7713358 | 0.83 | PDE4A (0.66) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6865665 | 0.81 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6755454 | 0.79 | PDE4A (0.69) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7389161 | 0.79 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL15761897 | 0.77 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7713350 | 0.77 | PDE4A (0.69) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL15790501 | 0.76 | PDE4A (0.52) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL2680219 | 0.76 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0766670-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH R&D LTD (GB) | 2002-03-27 | — | — | EP | claimed |
| US-5780477-A | Trisubstituted phenyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED (GB) | 1998-07-14 | — | — | US | claimed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |
| EP-0766670-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH R&D LTD (GB) | 2002-03-27 | — | — | EP | disclosed |
| US-6297264-B1 | E.G., 4-(2-BENZYLOXY-2-(3-CYCLOPENTYLOXY-4-METHOXYPHENYL)ETHYL)PYRID INE; PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 2001-10-02 | — | — | US | disclosed |
| US-5780477-A | Trisubstituted phenyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |