Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7389924 | 0.89 | GAA (0.42) | MAPTALDH1A1LMNANPC1MAPK1 | |
| SCHEMBL7390658 | 0.88 | ADAMTS5 (0.39) | GAA | |
| SCHEMBL7392280 | 0.84 | CYP1A2 (0.48) | ALDH1A1LMNAHTTNPC1MAPK1 | |
| SCHEMBL7883790 | 0.69 | CXCR4 (0.40) | ALDH1A1GAA | |
| SCHEMBL7898540 | 0.66 | NPC1 (0.53) | MAPTALDH1A1LMNAHTTNPC1 | |
| SCHEMBL7289769 | 0.66 | ALDH1A1 (0.43) | MAPTALDH1A1LMNAHTTNPC1 | |
| SCHEMBL17830370 | 0.65 | IDO1 (0.51) | MAPTLMNAHTTL3MBTL1 | |
| SCHEMBL10755504 | 0.65 | TSHR (0.44) | MAPTALDH1A1GAAL3MBTL1SMN1; SMN2 | |
| SCHEMBL20053035 | 0.65 | IDO1 (0.51) | MAPTLMNAHTTL3MBTL1 | |
| SCHEMBL15973700 | 0.65 | MEN1 (0.53) | MAPTALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1041726-C | 1.3-Dihydro-2H-Imidazo{4,5-6} Quinolin-2-One derivatives. | JANSSEN PHARMACEUTICA NV (BE) | 1999-01-20 | — | — | CN | disclosed |
| US-5541325-A | ENZYME INHIBITORS, ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-07-30 | — | — | US | disclosed |
| US-5521187-A | PHOSPHODIESTERASE INHIBITORS, ANTIALLERGENS AND ATOPIC DISEASES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-05-28 | — | — | US | disclosed |
| US-5516908-A | ANTIALLERGENS, ATROPIC DISEASES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-05-14 | — | — | US | disclosed |
| EP-0610372-B1 | 1,3-DIHYDRO-2H-IMIDAZO(4,5-B)QUINOLIN-2-ONE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 1995-12-13 | — | — | EP | disclosed |
| EP-0610372-A1 | 1,3-DIHYDRO-2H-IMIDAZO(4,5-B)QUINOLIN-2-ONE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS. | JANSSEN PHARMACEUTICA NV (BE) | 1994-08-17 | — | — | EP | disclosed |
| CN-1072681-A | 1,3-dihydro-2H-imidazo [4,5-b] quinoline-2-one-derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1993-06-02 | — | — | CN | disclosed |
| WO-1993009118-A1 | 1,3-DIHYDRO-2H-IMIDAZO(4,5-B)QUINOLIN-2-ONE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-05-13 | — | — | WO | disclosed |
| EP-0541153-A1 | 1,3-Dihydro-2H-imidazo[4,5-b]-quinolin-2-one derivatives as phosphodiesterase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-05-12 | — | — | EP | disclosed |