Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5795584 | 0.94 | MAOB (0.48) | MAOBNPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL335459 | 0.78 | — | — | |
| SCHEMBL28929654 | 0.77 | LMNA (0.43) | NPC1RAB9AKDM4EL3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5395245 | 0.76 | RAB9A (0.53) | MAOBNPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL2399420 | 0.75 | NPC1 (0.57) | NPC1RAB9AKDM4ESMN1; SMN2NFKB1 | |
| Hydrazine SCHEMBL3522472 | 0.74 | RAB9A (0.51) | MAOBNPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL6990088 | 0.73 | NPC1 (0.57) | NPC1RAB9AKDM4EL3MBTL1ALDH1A1 | |
| Pyrrole SCHEMBL9111233 | 0.73 | NPC1 (0.47) | MAOBNPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL8392453 | 0.72 | MAOB (0.57) | MAOBNPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL10919254 | 0.72 | NPC1 (0.47) | MAOBNPC1RAB9AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068187-A1 | PYRAZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999051580-A1 | PYRAZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES (US) | 1999-10-14 | — | — | WO | disclosed |