Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 15/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.46 |
| ▸ | PDE4A | P27815 | 6/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7356087 | 0.87 | PDE4B (0.48) | PDE4DGFERPDE4BPDE4APDE4C | |
| SCHEMBL7356090 | 0.86 | PDE4D (0.49) | PDE4DGFERPDE4BPDE4APDE4C | |
| SCHEMBL7351599 | 0.82 | PDE4D (0.60) | PDE4DGFERPDE4BPDE4APDE4C | |
| SCHEMBL7389479 | 0.81 | PDE4D (0.65) | PDE4DGFERPDE4BPDE4APDE4C | |
| SCHEMBL70307 | 0.80 | PDE4D (0.51) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7353637 | 0.77 | PDE4D (0.81) | PDE4DGFERPDE4BPDE4APDE4C | |
| SCHEMBL7353934 | 0.77 | PDE4B (0.50) | PDE4DGFERPDE4BPDE4APDE4C | |
| SCHEMBL70809 | 0.76 | PSMD14 (0.40) | GFERKCNQ3KCNQ2 | |
| SCHEMBL7359867 | 0.76 | XDH (0.46) | KCNQ3KCNQ2 | |
| SCHEMBL2889353 | 0.75 | PDE4D (0.68) | PDE4DPDE4BPDE4APDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |