Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.40 |
| ▸ | HRH1 | P35367 | 6/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739050 | 1.00 | DPP4 (0.40) | DPP4DPP8DPP9DPP7TP53 | |
| SCHEMBL739051 | 1.00 | DPP4 (0.40) | DPP4DPP8DPP9DPP7TP53 | |
| SCHEMBL741326 | 0.93 | KCNH2 (0.41) | DPP4TP53MAPTKCNH2HRH1 | |
| SCHEMBL741324 | 0.93 | KCNH2 (0.41) | DPP4TP53MAPTKCNH2HRH1 | |
| SCHEMBL741325 | 0.93 | KCNH2 (0.41) | DPP4TP53MAPTKCNH2HRH1 | |
| SCHEMBL739744 | 0.92 | HRH1 (0.45) | MAPTKCNH2HRH1CYP2D6CHRM1 | |
| SCHEMBL739743 | 0.92 | HRH1 (0.45) | MAPTKCNH2HRH1CYP2D6CHRM1 | |
| SCHEMBL739745 | 0.92 | HRH1 (0.45) | MAPTKCNH2HRH1CYP2D6CHRM1 | |
| SCHEMBL740534 | 0.92 | KCNH2 (0.40) | TP53SMN1; SMN2KCNH2HRH1CYP2D6 | |
| SCHEMBL741653 | 0.92 | L3MBTL1 (0.43) | TP53MAPTSMN1; SMN2KCNH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |