Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 11/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739745 | 1.00 | HRH1 (0.45) | HRH1KCNH2CYP2D6CHRM1USP2 | |
| SCHEMBL739744 | 1.00 | HRH1 (0.45) | HRH1KCNH2CYP2D6CHRM1USP2 | |
| SCHEMBL741326 | 0.94 | KCNH2 (0.41) | HRH1KCNH2CYP2D6CHRM1USP2 | |
| SCHEMBL741324 | 0.94 | KCNH2 (0.41) | HRH1KCNH2CYP2D6CHRM1USP2 | |
| SCHEMBL741325 | 0.94 | KCNH2 (0.41) | HRH1KCNH2CYP2D6CHRM1USP2 | |
| SCHEMBL740673 | 0.94 | GAA (0.47) | HRH1KCNH2CYP2D6CHRM1POLB | |
| SCHEMBL740674 | 0.94 | GAA (0.47) | HRH1KCNH2CYP2D6CHRM1POLB | |
| SCHEMBL740672 | 0.94 | GAA (0.47) | HRH1KCNH2CYP2D6CHRM1POLB | |
| SCHEMBL741655 | 0.92 | L3MBTL1 (0.43) | HRH1KCNH2CYP2D6CHRM1GAA | |
| SCHEMBL739050 | 0.92 | DPP4 (0.40) | HRH1KCNH2CYP2D6CHRM1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |