Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.60 |
| ▸ | ALPG | P10696 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HTR6 | P50406 | 1/20 | 0.55 |
| ▸ | FBP1 | P09467 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2220740 | 0.96 | MAPT (0.59) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL10576590 | 0.93 | LMNA (0.68) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL762553 | 0.87 | SMN1; SMN2 (0.60) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL8313477 | 0.86 | KAT2B (0.69) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL741469 | 0.85 | MAPT (0.70) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL6474886 | 0.85 | LMNA (0.57) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL1046670 | 0.85 | LMNA (0.57) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL7745956 | 0.85 | LMNA (0.57) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL29392855 | 0.84 | KAT2B (0.59) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL10580319 | 0.84 | MAPT (0.58) | MAPTLMNASMN1; SMN2TDP1ALPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |