Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 3/20 | 0.67 |
| ▸ | CTSL | P07711 | 5/20 | 0.53 |
| ▸ | MMP3 | P08254 | 5/20 | 0.49 |
| ▸ | MMP1 | P03956 | 4/20 | 0.49 |
| ▸ | MMP2 | P08253 | 4/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.45 |
| ▸ | CTSS | P25774 | 5/20 | 0.44 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7393762 | 0.84 | CACNA1B (0.51) | CACNA1BCTSLMMP3MMP1MMP2 | |
| SCHEMBL7387298 | 0.84 | CTSS (0.59) | CACNA1BCTSLMMP3MMP1MMP2 | |
| SCHEMBL11932026 | 0.80 | CACNA1B (1.00) | CACNA1BCTSLCTSS | |
| SCHEMBL25531422 | 0.80 | CACNA1B (1.00) | CACNA1BCTSLCTSS | |
| SCHEMBL7392894 | 0.79 | CACNA1B (0.54) | CACNA1BCTSL | |
| SCHEMBL7383871 | 0.77 | CACNA1B (0.45) | CACNA1BCTSLMMP3MMP1MMP2 | |
| SCHEMBL7383612 | 0.77 | CACNA1B (0.73) | CACNA1B | |
| SCHEMBL7390781 | 0.77 | CACNA1B (0.73) | CACNA1B | |
| SCHEMBL7383617 | 0.77 | CACNA1B (0.73) | CACNA1B | |
| SCHEMBL7385278 | 0.76 | CACNA1B (0.55) | CACNA1BCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458781-B1 | BLOCKERS CALCIUM CHANNEL ANTAGONISTS FOR STROKES, BRAIN DISORDERS | WARNER-LAMBERT COMPANY | 2002-10-01 | — | — | US | claimed |
| WO-1999055688-A1 | SUBSTITUTED DIARYLALKYL AMIDES AS CALCIUM CHANNEL ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1999-11-04 | — | — | WO | claimed |
| US-6458781-B1 | BLOCKERS CALCIUM CHANNEL ANTAGONISTS FOR STROKES, BRAIN DISORDERS | WARNER-LAMBERT COMPANY | 2002-10-01 | — | — | US | disclosed |
| WO-1999055688-A1 | SUBSTITUTED DIARYLALKYL AMIDES AS CALCIUM CHANNEL ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1999-11-04 | — | — | WO | disclosed |