SCHEMBL7391850

SCHEMBL7391850

O=C(O)[C@H](Cc1c[nH]cn1)N(Cc1ccccc1)C(=O)[C@@H]1CCC(=O)N1Cc1cccc(Cl)c1

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 6/20 0.41
NPC1 O15118 1/20 0.39
ITGB1 P05556 3/20 0.38
ITGA4 P13612 3/20 0.38
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38
HTT P42858 1/20 0.38
KMT2A Q03164 1/20 0.38
TP53 P04637 1/20 0.37
MDM2 Q00987 1/20 0.37
ALDH1A1 P00352 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
TSHR P16473 1/20 0.37
CYP2C19 P33261 1/20 0.37
PTGER4 P35408 1/20 0.36
PTGER2 P43116 1/20 0.36
USP2 O75604 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7389323 0.89 CYP2C19 (0.44) ITGB1ITGA4KDM4EMEN1HTT
SCHEMBL5164311 0.82 CYP2C19 (0.44) ITGB1ITGA4KDM4EMEN1HTT
SCHEMBL5163953 0.82 ITGB1 (0.50) ITGB1ITGA4KDM4EHTTKMT2A
SCHEMBL288849 0.71 P2RX7 (0.58) P2RX7NPC1MEN1HTTKMT2A
SCHEMBL1612852 0.71 P2RX7 (0.58) P2RX7NPC1MEN1HTTKMT2A
SCHEMBL2448764 0.71 P2RX7 (0.58) P2RX7NPC1MEN1HTTKMT2A
SCHEMBL30061816 0.71 P2RX7 (0.58) P2RX7NPC1MEN1HTTKMT2A
SCHEMBL6708108 0.69 ALDH1A1 (0.47) KDM4ETP53ALDH1A1TSHRUSP2
SCHEMBL19974972 0.69 P2RX7 (0.56) P2RX7NPC1MEN1HTTKMT2A
SCHEMBL16328230 0.68 P2RX7 (0.60) P2RX7NPC1KDM4EMEN1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144435-A2 PYROGLUTAMIC ACID DERIVATIVES AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2001-10-17 EP claimed
WO-2000043413-A2 PYROGLUTAMIC ACID DERIVATIVES AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS, INC. (US) 2000-07-27 WO claimed
EP-1144435-A2 PYROGLUTAMIC ACID DERIVATIVES AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2001-10-17 EP disclosed
WO-2000043413-A2 PYROGLUTAMIC ACID DERIVATIVES AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS, INC. (US) 2000-07-27 WO disclosed