SCHEMBL7392152

SCHEMBL7392152

COc1ccc(F)c(NC(=O)c2c[nH]c3c2C(=O)C(C)(C)CC3)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 1/20 0.47
ROCK1 Q13464 1/20 0.47
MAPK14 Q16539 2/20 0.40
TP53 P04637 2/20 0.38
GPR35 Q9HC97 1/20 0.38
SMN1; SMN2 Q16637 7/20 0.36
RAB9A P51151 5/20 0.36
NPC1 O15118 4/20 0.36
MAPT P10636 3/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
TAS1R3 Q7RTX0 1/20 0.36
TAS1R1 Q7RTX1 1/20 0.36
TAS1R2 Q8TE23 1/20 0.36
ABCB1 P08183 1/20 0.36
F10 P00742 1/20 0.36
ALDH1A1 P00352 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
HPGD P15428 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7395738 0.92 ROCK2 (0.47) ROCK2ROCK1GPR35SMN1; SMN2RAB9A
SCHEMBL7399760 0.83 ROCK2 (0.56) ROCK2ROCK1SMN1; SMN2RAB9ANPC1
SCHEMBL7395940 0.83 ROCK2 (0.61) ROCK2ROCK1TP53SMN1; SMN2RAB9A
SCHEMBL6771697 0.83 RXFP1 (0.44) MAPK14TP53GPR35SMN1; SMN2RAB9A
SCHEMBL7398344 0.83 DHODH (0.40) MAPK14TP53GPR35SMN1; SMN2RAB9A
SCHEMBL7358902 0.83 TP53 (0.40) MAPK14TP53GPR35SMN1; SMN2RAB9A
SCHEMBL7398250 0.82 ROCK2 (0.55) ROCK2ROCK1TP53SMN1; SMN2RAB9A
SCHEMBL7400004 0.82 ROCK2 (0.45) ROCK2ROCK1TP53MAPTMEN1
SCHEMBL7394552 0.81 ROCK2 (0.49) ROCK2ROCK1RAB9ANPC1MAPT
SCHEMBL7369380 0.77 ROCK2 (0.63) ROCK2ROCK1TP53SMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998002420-A9 CERTAIN FUSED PYRROLECARBOXANILIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS 1998-04-23 WO claimed
WO-1998002420-A1 CERTAIN FUSED PYRROLECARBOXANILIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 1998-01-22 WO claimed
US-5925770-A GAMMA-AMINOBUTYRIC ACID DERIVATIVES FOR DIAGNOSIS OR TREATMENT OF ANXIETY, SLEEP DISORDERS, SEIZURES, OVERDOSES OF BENZODIAZEPINE TYPE DRUGS, COGNITION ACTIVATORS NEUROGEN CORPORATION (US) 1999-07-20 US disclosed
US-5750702-A Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands NEUROGEN CORPORATION (US) 1998-05-12 US disclosed
WO-1998002420-A9 CERTAIN FUSED PYRROLECARBOXANILIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS 1998-04-23 WO disclosed
WO-1998002420-A1 CERTAIN FUSED PYRROLECARBOXANILIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 1998-01-22 WO disclosed