Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11880693 | 0.86 | TDP1 (0.44) | HPGDSMN1; SMN2HSD17B10KDM4EMEN1 | |
| Hydroxyamine SCHEMBL7069519 | 0.84 | TDP1 (0.53) | HPGDSMN1; SMN2HSD17B10TDP1PPARG | |
| SCHEMBL9430038 | 0.82 | SHMT2 (0.48) | HPGDSMN1; SMN2HSD17B10KDM4EMEN1 | |
| SCHEMBL11822590 | 0.80 | TDP1 (0.48) | HPGDSMN1; SMN2HSD17B10KDM4EMEN1 | |
| SCHEMBL11822708 | 0.80 | SMN1; SMN2 (0.45) | HPGDSMN1; SMN2HSD17B10KDM4EMEN1 | |
| SCHEMBL22446603 | 0.80 | SMN1; SMN2 (0.41) | HPGDSMN1; SMN2HSD17B10KDM4EALDH1A1 | |
| SCHEMBL8856859 | 0.79 | — | — | |
| SCHEMBL11875291 | 0.79 | MAPT (0.40) | MMP9HPGDSMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL6932388 | 0.79 | HTT (0.43) | MMP9MMP13ADAM17MEN1KMT2A | |
| SCHEMBL7509127 | 0.77 | MMP9 (0.44) | MMP9MMP13ADAM17HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172057-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; ANTITUMOR AGENTS | AMERICAN CYANAMID COMPANY | 2001-01-09 | — | — | US | disclosed |