SCHEMBL739325

SCHEMBL739325

[O]N1CCCCCC1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12813 1.00
SCHEMBL2250575 1.00
SCHEMBL129150 0.95
SCHEMBL825746 0.80
SCHEMBL834059 0.80
Diethylamine SCHEMBL27883551 0.76 TP53 (0.42)
Fluoride Ion SCHEMBL816398 0.67 MGLL (0.32)
SCHEMBL23810072 0.61 CYP2D6 (0.33)
SCHEMBL6926105 0.60 MGLL (0.40)
SCHEMBL42220 0.60 MGLL (0.40)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 159 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240197711-A1 Combination Therapy for Cancer Treatment REGENTS OF THE UNIVERSITY OF MICHIGAN 2024-06-20 US claimed
US-20240124419-A1 SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2024-04-18 US claimed
EP-4313029-A1 COMBINATION THERAPY FOR CANCER TREATMENT The Regents of The University of Michigan (US) 2024-02-07 EP claimed
CN-117337175-A Combination Therapy for Cancer Treatment 密歇根大学董事会 2024-01-02 CN claimed
EP-4288416-A2 SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF The Regents Of The University Of Michigan (US) 2023-12-13 EP claimed
US-20230098205-A1 INHIBITORS OF EGFR, KRAS, BRAF, AND OTHER TARGETS AND USE OF THE SAME THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2023-03-30 US claimed
US-20230097789-A1 INHIBITORS OF EGFR, KRAS, BRAF, AND OTHER TARGETS AND USE OF THE SAME UNIV MICHIGAN REGENTS (US) 2023-03-30 US claimed
EP-4114387-A1 INHIBITORS OF EGFR, KRAS, BRAF, AND OTHER TARGETS AND USE OF THE SAME The Regents of The University of Michigan (US) 2023-01-11 EP claimed
EP-4114386-A1 INHIBITORS OF EGFR, KRAS, BRAF, AND OTHER TARGETS AND USE OF THE SAME The Regents of The University of Michigan (US) 2023-01-11 EP claimed
WO-2022169834-A2 SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2022-08-11 WO claimed
EP-1165566-B1 PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS OF CYTOKINE MEDIATED DISEASE ASTRAZENECA AB (SE) 2003-08-20 EP claimed
US-6548514-B1 Inhibitors of p38 kinase/cytokine suppressive binding protein (CSBP)/reactivating kinase (RK); 1-((pyridyl)aminocarbonyl)-3-((hetero)arylaminocarbonyl)benzene derivatives; treating cytokine related diseases and disorders ASTRAZENECA AB (SE) 2003-04-15 US claimed
JP-2002540112-A 2002-11-26 JP claimed
JP-2002539187-A 2002-11-19 JP claimed
EP-1165566-A1 PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS OF CYTOKINE MEDIATED DISEASE AstraZeneca AB (SE) 2002-01-02 EP claimed
EP-1163212-A1 AMIDE DERIVATIVES AstraZeneca AB (SE) 2001-12-19 EP claimed
EP-1163237-A1 AMIDE DERIVATIVES AstraZeneca AB (SE) 2001-12-19 EP claimed
WO-2000056738-A1 PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS OF CYTOKINE MEDIATED DISEASE ASTRAZENECA AB (SE) 2000-09-28 WO claimed
WO-2000055120-A1 AMIDE DERIVATIVES ASTRAZENECA AB (SE) 2000-09-21 WO claimed
WO-2000055153-A1 AMIDE DERIVATIVES ASTRAZENECA AB (SE) 2000-09-21 WO claimed