Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 7/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742017 | 0.92 | NLRP3 (0.41) | HRH1KCNH2CYP2D6NLRP3TP53 | |
| SCHEMBL740088 | 0.92 | HRH1 (0.45) | HRH1KCNH2CYP2D6CHRM1HTR2B | |
| SCHEMBL763422 | 0.92 | HRH1 (0.37) | HRH1KCNH2CYP2D6NLRP3TP53 | |
| SCHEMBL740685 | 0.90 | HRH1 (0.40) | HRH1KCNH2CYP2D6NLRP3TP53 | |
| SCHEMBL740684 | 0.90 | HRH1 (0.40) | HRH1KCNH2CYP2D6NLRP3TP53 | |
| SCHEMBL739892 | 0.88 | HRH1 (0.43) | HRH1KCNH2CYP2D6CHRM1PROKR1 | |
| SCHEMBL740312 | 0.86 | HRH1 (0.45) | HRH1KCNH2CYP2D6TP53CHRM1 | |
| SCHEMBL739919 | 0.86 | HRH1 (0.45) | HRH1KCNH2CYP2D6CHRM1 | |
| SCHEMBL742630 | 0.85 | HRH1 (0.42) | HRH1KCNH2CYP2D6CHRM1 | |
| SCHEMBL738642 | 0.85 | HRH1 (0.41) | HRH1KCNH2CYP2D6CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |