Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL763858 | 0.93 | KCNH2 (0.42) | HRH1KCNH2CYP2D6KLK5ACE | |
| SCHEMBL762527 | 0.92 | NLRP3 (0.39) | HRH1KCNH2CYP2D6KLK5NLRP3 | |
| SCHEMBL739362 | 0.92 | HRH1 (0.40) | HRH1KCNH2CYP2D6NLRP3TP53 | |
| SCHEMBL763874 | 0.90 | HRH1 (0.39) | HRH1KCNH2CYP2D6KLK5CHRM1 | |
| SCHEMBL739547 | 0.89 | HRH1 (0.41) | HRH1KCNH2CYP2D6KLK5HRH2 | |
| SCHEMBL739548 | 0.89 | HRH1 (0.41) | HRH1KCNH2CYP2D6KLK5HRH2 | |
| SCHEMBL16301222 | 0.89 | HRH1 (0.38) | HRH1KCNH2CYP2D6TP53THRB | |
| SCHEMBL16301236 | 0.88 | KCNH2 (0.47) | HRH1KCNH2CYP2D6TP53SMN1; SMN2 | |
| SCHEMBL16301237 | 0.88 | HRH1 (0.40) | HRH1KCNH2CYP2D6KLK5CHRM1 | |
| SCHEMBL739119 | 0.88 | HRH1 (0.39) | HRH1KCNH2CYP2D6HRH2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |