Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 3/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | EED | O75530 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30874548 | 1.00 | PNMT (0.40) | PNMTABCG2EEDLTA4HDPP4 | |
| SCHEMBL31634143 | 0.85 | ABCG2 (0.39) | ABCG2EED | |
| SCHEMBL28778285 | 0.81 | ABCG2 (0.37) | ABCG2EED | |
| SCHEMBL19500892 | 0.81 | GABRA1 (0.38) | ABCG2 | |
| SCHEMBL28778284 | 0.81 | ABCG2 (0.37) | ABCG2EED | |
| SCHEMBL29754286 | 0.80 | ABCG2 (0.35) | ABCG2EED | |
| SCHEMBL31405445 | 0.79 | ABCG2 (0.34) | ABCG2EED | |
| SCHEMBL31405456 | 0.79 | ABCG2 (0.34) | ABCG2EED | |
| SCHEMBL28778288 | 0.79 | ABCG2 (0.34) | ABCG2EED | |
| SCHEMBL9666927 | 0.77 | ABCG2 (0.33) | ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114338-A | ENZYME INHIBITORS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-09-05 | — | — | US | disclosed |
| US-6001830-A | INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE, OR ADDITIONALLY OF THROMBOXANE A.SUB.2 SYNTHETASE; TRIAZOLOPYRIDAZINE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-12-14 | — | — | US | disclosed |
| US-5869486-A | EXHIBIT INHIBITORY ACTIVITY ON CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE; ADMINISTERING TO TREAT CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-02-09 | — | — | US | disclosed |
| EP-0728759-A1 | Heterocyclic compounds | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-28 | — | — | EP | disclosed |