Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.64 |
| ▸ | PDE4A | P27815 | 10/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7907860 | 0.90 | PDE5A (0.67) | PDE5APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL4162765 | 0.87 | PDE5A (0.70) | PDE5APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL27472680 | 0.86 | PDE4D (0.68) | PDE5APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL30009845 | 0.84 | PDE4B (0.80) | PDE4DPDE4APDE4BPDE4CMAPK14 | |
| SCHEMBL1028427 | 0.84 | PDE4B (0.80) | PDE4DPDE4APDE4BPDE4CMAPK14 | |
| SCHEMBL31527683 | 0.84 | LMNA (0.67) | — | |
| SCHEMBL1443872 | 0.84 | LMNA (0.67) | — | |
| SCHEMBL9005494 | 0.83 | PDE4D (0.78) | PDE4DPDE4APDE4BPDE4CMAPK14 | |
| Hydrochloric Acid SCHEMBL6586041 | 0.83 | PDE4B (0.78) | PDE4DPDE4APDE4BPDE4CMAPK14 | |
| SCHEMBL7336609 | 0.83 | PDE4D (0.78) | PDE4DPDE4APDE4BPDE4CMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934933-A1 | Phthalazinones | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |