Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 8/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7394379 | 0.90 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTKMT2AMEN1GAA | |
| SCHEMBL30354865 | 0.75 | NPC1 (0.77) | SMN1; SMN2MAPTKMT2AMEN1GAA | |
| SCHEMBL1662880 | 0.74 | MEN1 (0.77) | SMN1; SMN2MAPTKMT2AMEN1GAA | |
| SCHEMBL22080088 | 0.74 | RAB9A (0.67) | SMN1; SMN2MAPTKMT2AMEN1GAA | |
| SCHEMBL31687019 | 0.73 | RAB9A (0.68) | SMN1; SMN2KMT2AMEN1GAAALDH1A1 | |
| SCHEMBL7395650 | 0.73 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTKMT2AMEN1GAA | |
| SCHEMBL7379409 | 0.72 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPTKMT2AMEN1GAA | |
| SCHEMBL7655135 | 0.72 | RAD52 (0.61) | SMN1; SMN2MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL7690590 | 0.72 | RAB9A (0.84) | SMN1; SMN2MAPTKMT2AMEN1GAA | |
| SCHEMBL6640374 | 0.72 | KCNJ1 (0.53) | SMN1; SMN2MAPTKMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100795-A1 | DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT | BOEHRINGER INGELHEIM ZENTRALE GMBH (DE) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000008014-A1 | DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-02-17 | — | — | WO | disclosed |