Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7379738 | 0.83 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL7394263 | 0.81 | RPS6KA3 (0.42) | SMN1; SMN2KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL7394379 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL7394384 | 0.72 | SMN1; SMN2 (0.56) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL7690658 | 0.72 | RAB9A (0.56) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL7393202 | 0.72 | SMN1; SMN2 (0.42) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL6640374 | 0.68 | KCNJ1 (0.53) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL7452119 | 0.68 | MAOB (0.45) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL6142607 | 0.66 | RPS6KA3 (0.60) | SMN1; SMN2KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL8553989 | 0.65 | RAB9A (0.47) | SMN1; SMN2KMT2ALMNAHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000050419-A1 | SUBSTITUTED BICYCLIC HETEROCYCLES AND THE USE THEREOF AS THROMBIN INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-08-31 | — | — | WO | disclosed |