Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | CKS1B | P61024 | 1/20 | 0.48 |
| ▸ | SKP1 | P63208 | 1/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | ACACB | O00763 | 10/20 | 0.43 |
| ▸ | ACACA | Q13085 | 8/20 | 0.43 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.42 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7391345 | 0.86 | DRD2 (0.50) | NAMPTCKS1BSKP1SKP2DRD2 | |
| SCHEMBL7390125 | 0.85 | NAMPT (0.49) | NAMPTCKS1BSKP1SKP2DRD2 | |
| SCHEMBL7388880 | 0.84 | CKS1B (0.52) | NAMPTCKS1BSKP1SKP2DRD2 | |
| SCHEMBL9005377 | 0.84 | CKS1B (0.52) | NAMPTCKS1BSKP1SKP2DRD2 | |
| SCHEMBL7389331 | 0.83 | NAMPT (0.47) | NAMPTCKS1BSKP1SKP2DRD2 | |
| SCHEMBL7392880 | 0.83 | NAMPT (0.47) | NAMPTCKS1BSKP1SKP2DRD2 | |
| SCHEMBL9005360 | 0.81 | CKS1B (0.44) | NAMPTCKS1BSKP1SKP2DRD2 | |
| SCHEMBL13488656 | 0.78 | CDK5 (0.52) | KIF18A | |
| SCHEMBL24322378 | 0.77 | KIF18A (0.52) | CKS1BSKP1SKP2DRD2KIF18A | |
| SCHEMBL29497116 | 0.77 | KIF18A (0.52) | CKS1BSKP1SKP2DRD2KIF18A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576320-A | 1-heteruarylazetidines and -pyrrolidines, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1996-11-19 | — | — | US | disclosed |
| US-5565474-A | 1-heteroarylazetidines and -pyrrolidines process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1996-10-15 | — | — | US | disclosed |
| US-5410057-A | 1-heteroarylazetidines and -pyrrolidines | SANOFI (FR) | 1995-04-25 | — | — | US | disclosed |
| EP-0591030-A2 | 1-Heteroaryl-azetidines and -pyrrolidines as 5-HT3 agonists | SANOFI (FR) | 1994-04-06 | — | — | EP | disclosed |