Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313477 | 0.89 | KAT2B (0.69) | KAT2BALDH1A1LMNAPOLBKDM4E | |
| SCHEMBL4858189 | 0.83 | KAT2B (0.74) | KAT2BALDH1A1POLBHCAR3KDM4E | |
| SCHEMBL29580274 | 0.83 | KAT2B (0.74) | KAT2BALDH1A1POLBHCAR3KDM4E | |
| SCHEMBL14906561 | 0.83 | KAT2B (0.74) | KAT2BALDH1A1LMNAPOLBHCAR3 | |
| SCHEMBL29416813 | 0.83 | KAT2B (1.00) | KAT2BALDH1A1LMNAPOLBMAPT | |
| SCHEMBL10113238 | 0.83 | KAT2B (1.00) | KAT2BALDH1A1LMNAPOLBMAPT | |
| SCHEMBL16151564 | 0.82 | KAT2B (0.72) | KAT2BALDH1A1LMNAPOLBHCAR3 | |
| SCHEMBL4863416 | 0.82 | KAT2B (0.72) | KAT2BALDH1A1LMNAPOLBHCAR3 | |
| Hydrochloric Acid SCHEMBL513245 | 0.82 | KAT2B (1.00) | KAT2BALDH1A1LMNAPOLBMAPT | |
| SCHEMBL6023906 | 0.82 | KAT2B (0.54) | KAT2BALDH1A1LMNAPOLBHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |