Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1242072 | 0.87 | DDB1 (0.52) | DDB1CRBNKCNH2IDO1GAA | |
| SCHEMBL30936699 | 0.81 | ALDH1A1 (0.43) | DDB1CRBNKCNH2IDO1GAA | |
| SCHEMBL29157521 | 0.79 | DDB1 (0.55) | DDB1CRBNIDO1ALDH1A1DPP4 | |
| SCHEMBL1240861 | 0.78 | EPHX2 (0.39) | IDO1GAAJAK3JAK2JAK1 | |
| SCHEMBL6229055 | 0.78 | GAA (0.41) | DDB1CRBNIDO1GAAJAK3 | |
| SCHEMBL1717738 | 0.77 | DDB1 (0.39) | DDB1CRBNIDO1GAAJAK3 | |
| SCHEMBL1241520 | 0.74 | S1PR3 (0.39) | JAK3ALDH1A1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL28111070 | 0.74 | DDB1 (0.31) | DDB1CRBNDPP4DPP9DPP8 | |
| SCHEMBL1241612 | 0.74 | MAPT (0.39) | DDB1CRBNKCNH2IDO1GAA | |
| SCHEMBL1136265 | 0.74 | HTT (0.56) | KCNH2IDO1ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138185-B2 | Urea glucokinase activators | NOVO NORDISK A/S (DK) | 2012-03-20 | — | — | US | disclosed |
| US-20100009989-A1 | Urea Glucokinase Activators | NOVO NORDISK A/S (DK) | 2010-01-14 | — | — | US | disclosed |
| EP-2118083-A1 | UREA GLUCOKINASE ACTIVATORS | Novo Nordisk A/S (DK) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008084043-A1 | UREA GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009989-A1 | Urea Glucokinase Activators | GCK, GCKR, HK2 | PSEN1 3149/4885PSEN2 1740/4885APH1B 2445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.