Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.48 |
| ▸ | PTGFR | P43088 | 1/20 | 0.48 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.48 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.48 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7396139 | 1.00 | MAOB (0.65) | MAOBKDM4ELMNATBXA2RPTGER4 | |
| SCHEMBL7394709 | 0.81 | MAOB (0.59) | MAOBKDM4EHDAC8HDAC6POLB | |
| SCHEMBL7394712 | 0.81 | MAOB (0.59) | MAOBKDM4EHDAC8HDAC6POLB | |
| SCHEMBL8746644 | 0.81 | KDM4E (0.50) | MAOBKDM4ELMNATBXA2RPTGER4 | |
| SCHEMBL765995 | 0.81 | CYP1B1 (0.54) | MAOBKDM4ELMNATBXA2RPTGER4 | |
| SCHEMBL765996 | 0.81 | CYP1B1 (0.54) | MAOBKDM4ELMNATBXA2RPTGER4 | |
| SCHEMBL21662321 | 0.80 | MAOB (0.78) | MAOBKDM4ELMNAHDAC8HDAC6 | |
| SCHEMBL28723354 | 0.79 | MAOB (0.67) | MAOBNFKB1CYP1A1CYP1B1RAB9A | |
| SCHEMBL600540 | 0.79 | HDAC8 (0.67) | KDM4EHDAC8HDAC6CA1CA2 | |
| SCHEMBL29404405 | 0.79 | HDAC8 (0.67) | KDM4EHDAC8HDAC6CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288261-B1 | DRUGS FOR INHIBITION OF ENZYMES | ABBOTT LABORATORIES | 2001-09-11 | — | — | US | disclosed |
| WO-2000037433-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 2000-06-29 | — | — | WO | disclosed |