Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.77 |
| ▸ | DRD4 | P21917 | 6/20 | 0.77 |
| ▸ | CA12 | O43570 | 1/20 | 0.77 |
| ▸ | CA1 | P00915 | 1/20 | 0.77 |
| ▸ | CA2 | P00918 | 1/20 | 0.77 |
| ▸ | CA4 | P22748 | 1/20 | 0.77 |
| ▸ | CA6 | P23280 | 1/20 | 0.77 |
| ▸ | CA5A | P35218 | 1/20 | 0.77 |
| ▸ | CA7 | P43166 | 1/20 | 0.77 |
| ▸ | CA9 | Q16790 | 1/20 | 0.77 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.77 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.77 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.77 |
| ▸ | HTR2A | P28223 | 7/20 | 0.68 |
| ▸ | HTR1A | P08908 | 5/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.68 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.68 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.68 |
| ▸ | DRD1 | P21728 | 1/20 | 0.68 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7396151 | 1.00 | DRD2 (0.77) | DRD2DRD4CA12CA1CA2 | |
| SCHEMBL7400396 | 0.89 | DRD2 (0.72) | DRD2DRD4CA12CA1CA2 | |
| SCHEMBL7400398 | 0.89 | DRD2 (0.72) | DRD2DRD4CA12CA1CA2 | |
| SCHEMBL7405953 | 0.88 | DRD2 (0.70) | DRD2DRD4CA12CA1CA2 | |
| Sonepiprazole SCHEMBL29385565 | 0.87 | DRD2 (1.00) | DRD2DRD4CA12CA1CA2 | |
| Sonepiprazole SCHEMBL5699034 | 0.87 | DRD2 (1.00) | DRD2DRD4CA12CA1CA2 | |
| Sonepiprazole SCHEMBL5698967 | 0.87 | DRD2 (1.00) | DRD2DRD4CA12CA1CA2 | |
| Sonepiprazole SCHEMBL7397229 | 0.87 | DRD2 (1.00) | DRD2DRD4CA12CA1CA2 | |
| SCHEMBL8297851 | 0.87 | DRD2 (0.72) | DRD2DRD4CA12CA1CA2 | |
| Sonepiprazole SCHEMBL29530780 | 0.87 | DRD2 (0.91) | DRD2DRD4CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737189-B1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS | UPJOHN CO (US) | 1999-07-28 | — | — | EP | claimed |
| EP-0737189-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1996-10-16 | — | — | EP | claimed |
| WO-1995018118-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS | THE UPJOHN COMPANY (US) | 1995-07-06 | — | — | WO | claimed |