Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Sonepiprazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 9/20 | 0.91 |
| ▸ | DRD4 known ✓ | P21917 | 6/20 | 0.91 |
| ▸ | HTR2A known ✓ | P28223 | 7/20 | 0.66 |
| ▸ | HTR1A known ✓ | P08908 | 5/20 | 0.66 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.66 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.66 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.66 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.66 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.66 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.66 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.66 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.66 |
| ▸ | HTR1D known ✓ | P28221 | 9/20 | 0.65 |
| ▸ | HTR1B known ✓ | P28222 | 2/20 | 0.51 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.91 |
| ▸ | CA2 | P00918 | 3/20 | 0.91 |
| ▸ | CA7 | P43166 | 3/20 | 0.91 |
| ▸ | CA9 | Q16790 | 2/20 | 0.91 |
| ▸ | CA12 | O43570 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sonepiprazole SCHEMBL7405948 | 1.00 | DRD2 (0.91) | DRD2DRD4CA1CA2CA7 | |
| Sonepiprazole SCHEMBL5699034 | 0.95 | DRD2 (1.00) | DRD2DRD4CA1CA2CA7 | |
| Sonepiprazole SCHEMBL29385565 | 0.95 | DRD2 (1.00) | DRD2DRD4CA1CA2CA7 | |
| Sonepiprazole SCHEMBL5698967 | 0.95 | DRD2 (1.00) | DRD2DRD4CA1CA2CA7 | |
| Sonepiprazole SCHEMBL7397229 | 0.95 | DRD2 (1.00) | DRD2DRD4CA1CA2CA7 | |
| Sonepiprazole SCHEMBL7404372 | 0.94 | DRD2 (0.98) | DRD2DRD4CA1CA2CA7 | |
| SCHEMBL7399904 | 0.91 | DRD2 (0.92) | DRD2DRD4CA1CA2CA7 | |
| SCHEMBL7401894 | 0.89 | DRD2 (0.89) | DRD2DRD4CA1CA2CA7 | |
| SCHEMBL7398840 | 0.89 | DRD2 (0.84) | DRD2DRD4CA1CA2CA7 | |
| SCHEMBL7396153 | 0.87 | DRD2 (0.77) | DRD2DRD4CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114480291-A | Cell lines and methods for detecting biological activity of dopamine D4 target compound | 上海枢境生物科技有限公司 | 2022-05-13 | — | — | CN | disclosed |