Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 12/20 | 0.36 |
| ▸ | SPHK2 | Q9NRA0 | 10/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CFB | P00751 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7432079 | 0.92 | NOS3 (0.38) | ALDH1A1LMNASPHK1SPHK2NOS3 | |
| SCHEMBL7390644 | 0.85 | NOS3 (0.36) | ALDH1A1NOS3NOS2MAPK1CRHBP | |
| SCHEMBL7400302 | 0.83 | CXCR4 (0.34) | ALDH1A1LMNASPHK1SPHK2NOS3 | |
| SCHEMBL7382709 | 0.81 | NOS3 (0.40) | ALDH1A1LMNANOS3NOS2MAPK1 | |
| SCHEMBL7423018 | 0.79 | NOS3 (0.40) | ALDH1A1LMNANOS3NOS2MAPK1 | |
| SCHEMBL7423582 | 0.78 | NOS2 (0.41) | NOS3NOS2 | |
| SCHEMBL7417662 | 0.73 | NOS2 (0.41) | NOS3NOS2 | |
| SCHEMBL7394461 | 0.72 | NOS3 (0.31) | NOS3NOS2 | |
| Hydrochloric Acid SCHEMBL7383900 | 0.72 | NOS3 (0.40) | NOS3NOS2 | |
| SCHEMBL7594951 | 0.72 | NOS3 (0.39) | NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000073312-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2000-12-07 | — | — | WO | claimed |
| WO-2000073312-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2000-12-07 | — | — | WO | disclosed |