Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7393716 | 0.79 | POLB (0.53) | NPC1RAB9ASMN1; SMN2CHRM1CHRM3 | |
| SCHEMBL7395446 | 0.78 | CA1 (0.45) | NPC1RAB9AAOC3CA1CA2 | |
| SCHEMBL21889030 | 0.74 | AOC3 (0.54) | NPC1RAB9ASMN1; SMN2CHRM1CHRM3 | |
| SCHEMBL7398146 | 0.72 | CHRM1 (0.47) | NPC1RAB9ASMN1; SMN2CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL23148960 | 0.72 | CHRM1 (0.47) | NPC1RAB9ASMN1; SMN2CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL29616565 | 0.72 | CHRM1 (0.47) | NPC1RAB9ASMN1; SMN2CHRM1CHRM3 | |
| SCHEMBL21914546 | 0.71 | AOC3 (0.59) | NPC1RAB9ASMN1; SMN2CHRM1CHRM3 | |
| SCHEMBL16864754 | 0.71 | FABP4 (0.49) | NPC1RAB9ASMN1; SMN2CHRM1CHRM3 | |
| SCHEMBL15614828 | 0.71 | FABP4 (0.49) | NPC1RAB9ASMN1; SMN2AOC3CA1 | |
| SCHEMBL7397407 | 0.70 | CASP3 (0.46) | NPC1RAB9ASMN1; SMN2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330990-A | Antagonists of 5-HT and 5-HT3 receptors, psychological disorders, antinausea | NOVO NORDISK A/S (DK) | 1994-07-19 | — | — | US | disclosed |
| EP-0419397-B1 | Substituted urea compounds and their preparation and use | NOVO NORDISK AS (DK) | 1994-06-08 | — | — | EP | disclosed |
| EP-0491770-A1 | SUBSTITUTED UREA COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-07-01 | — | — | EP | disclosed |
| EP-0419397-A1 | Substituted urea compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1991-03-27 | — | — | EP | disclosed |
| WO-1991003475-A1 | SUBSTITUTED UREA COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-03-21 | — | — | WO | disclosed |