Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 9/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 3/20 | 0.47 |
| ▸ | CNR1 | P21554 | 5/20 | 0.47 |
| ▸ | CNR2 | P34972 | 4/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955741 | 0.89 | MEN1 (0.53) | MEN1KMT2ASMN1; SMN2HTR3ACNR1 | |
| Hydrochloric Acid SCHEMBL7393720 | 0.87 | KDM4E (0.53) | HTR4KCNH2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6955313 | 0.87 | SMN1; SMN2 (0.51) | MEN1KMT2ASMN1; SMN2HTR3ACNR1 | |
| SCHEMBL7395613 | 0.87 | HTR4 (0.52) | HTR4KCNH2MEN1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7394157 | 0.86 | KDM4E (0.55) | HTR4KCNH2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6948551 | 0.86 | CNR1 (0.53) | MEN1KMT2ASMN1; SMN2HTR3ACNR1 | |
| SCHEMBL9055133 | 0.86 | CARM1 (0.56) | HTR4KCNH2HTR3AHTR2A | |
| SCHEMBL6950281 | 0.85 | CNR1 (0.56) | MEN1KMT2ASMN1; SMN2CNR1CNR2 | |
| SCHEMBL6950902 | 0.85 | HSD17B10 (0.51) | HTR4KCNH2MEN1KMT2ASMN1; SMN2 | |
| Oxalic Acid SCHEMBL7400227 | 0.85 | SLC6A2 (0.54) | HTR4KCNH2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0732333-B1 | Indazolecarboxamides | LILLY CO ELI (US) | 2001-08-01 | — | — | EP | disclosed |
| US-5817676-A | 5-HT4 RECEPTOR ANTAGONISTS, CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 1998-10-06 | — | — | US | disclosed |
| US-5798367-A | ANTAGONIZE 5-HYDROXYTRYPTAMINE RECEPTOR IN GASTROINTESTINAL TRACT OR GENITOURINARY TRACT | ELI LILLY AND COMPANY (US) | 1998-08-25 | — | — | US | disclosed |
| US-5654320-A | SEROTONIN RECEPTOR ANTAGONIST | ELI LILLY AND COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| WO-1996033713-A1 | INDAZOLECARBOXAMIDES | ELI LILLY AND COMPANY (US) | 1996-10-31 | — | — | WO | disclosed |
| EP-0732333-A1 | Indazolecarboxamides | ELI LILLY AND COMPANY (US) | 1996-09-18 | — | — | EP | disclosed |