Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.39 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443464 | 0.95 | SLC1A2 (0.40) | ALDH1A1SLC1A2LMNAMEN1KMT2A | |
| SCHEMBL7364580 | 0.83 | ALDH1A1 (0.38) | ALDH1A1SLC1A2LMNAMEN1KMT2A | |
| SCHEMBL7581255 | 0.81 | ALDH1A1 (0.59) | ALDH1A1LMNAMEN1KMT2AKDM4E | |
| SCHEMBL4728813 | 0.79 | ALDH1A1 (0.55) | ALDH1A1LMNAMEN1KMT2ATP53 | |
| SCHEMBL21245055 | 0.75 | ALDH1A1 (0.50) | ALDH1A1LMNAMEN1KMT2ATP53 | |
| SCHEMBL7494619 | 0.73 | EPHX1 (0.45) | ALDH1A1SLC1A2LMNAMEN1KMT2A | |
| SCHEMBL7486399 | 0.71 | SLC1A2 (0.44) | ALDH1A1SLC1A2LMNAMEN1KMT2A | |
| SCHEMBL9180285 | 0.70 | ALDH1A1 (0.43) | ALDH1A1LMNAMEN1KMT2ATP53 | |
| SCHEMBL28480892 | 0.69 | ALDH1A1 (0.77) | ALDH1A1LMNAMEN1KMT2AKDM4E | |
| SCHEMBL14896515 | 0.68 | SLC1A2 (0.55) | ALDH1A1SLC1A2LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |