Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A2 | P43004 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GRM8 | O00222 | 1/20 | 0.44 |
| ▸ | GRM6 | O15303 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.38 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7494619 | 0.98 | EPHX1 (0.45) | SLC1A2KDM4ECYP2C9CYP2C19GRM8 | |
| SCHEMBL7490484 | 0.96 | SLC1A2 (0.44) | SLC1A2KDM4ECYP2C9CYP2C19GRM8 | |
| SCHEMBL7486740 | 0.73 | ALDH1A1 (0.39) | KDM4EMEN1KMT2AEPHX1ALDH1A1 | |
| SCHEMBL11197502 | 0.73 | EPHX1 (0.64) | KDM4EEPHX1ALDH1A1 | |
| SCHEMBL7397703 | 0.71 | ALDH1A1 (0.46) | SLC1A2KDM4ECYP2C9CYP2C19GRM8 | |
| SCHEMBL7443464 | 0.68 | SLC1A2 (0.40) | SLC1A2KDM4ECYP2C9CYP2C19GRM8 | |
| SCHEMBL2848894 | 0.68 | EPHX1 (0.56) | KDM4ECYP2C9CYP2C19LMNAMEN1 | |
| SCHEMBL17316191 | 0.66 | EPHX1 (0.61) | KDM4ECYP2C9CYP2C19LMNAMEN1 | |
| SCHEMBL7144202 | 0.66 | — | — | |
| SCHEMBL14671468 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |