Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 15/20 | 0.61 |
| ▸ | MMP9 | P14780 | 15/20 | 0.61 |
| ▸ | MMP14 | P50281 | 14/20 | 0.61 |
| ▸ | MMP8 | P22894 | 14/20 | 0.61 |
| ▸ | MMP7 | P09237 | 2/20 | 0.61 |
| ▸ | ANPEP | P15144 | 1/20 | 0.59 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.59 |
| ▸ | MMP11 | P24347 | 2/20 | 0.58 |
| ▸ | MME | P08473 | 2/20 | 0.56 |
| ▸ | ECE1 | P42892 | 2/20 | 0.56 |
| ▸ | NMBR | P28336 | 1/20 | 0.55 |
| ▸ | MMP13 | P45452 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7393708 | 0.89 | NMBR (0.57) | MMP2MMP9MMP14MMP8MMP7 | |
| SCHEMBL7393705 | 0.88 | MMP2 (0.56) | MMP2MMP9MMP14MMP8MMP7 | |
| SCHEMBL7391501 | 0.82 | MME (0.62) | MMP2MMP9MMP14MMP8MMP7 | |
| SCHEMBL9068979 | 0.81 | MME (0.60) | MMP2MMP9MMP14MMP8MMP7 | |
| SCHEMBL12203727 | 0.80 | NMBR (0.70) | MMP2MMP9MMP14MMP8MME | |
| SCHEMBL6841178 | 0.80 | NMBR (0.70) | MMP2MMP9MMP14MMP8MME | |
| SCHEMBL1711383 | 0.79 | NMBR (0.73) | MMP2MMP9MMP14MMP8MMP7 | |
| SCHEMBL29472048 | 0.79 | NMBR (0.73) | MMP2MMP9MMP14MMP8MMP7 | |
| SCHEMBL5381814 | 0.79 | NMBR (0.73) | MMP2MMP9MMP14MMP8MMP7 | |
| SCHEMBL14027422 | 0.76 | NMBR (0.66) | MMP2MMP9MMP14MMP8MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993011154-A1 | INHIBITORS OF THE CONVERSION OF BIG ENDOTHELIN TO ENDOTHELIN | BERLEX LABORATORIES, INC. (US) | 1993-06-10 | — | — | WO | claimed |