Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL9 | O00512 | 1/20 | 0.60 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.51 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.51 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10996747 | 0.84 | BCL9 (0.65) | BCL9CTNNB1GAAPTPN7PTPN12 | |
| SCHEMBL27560276 | 0.81 | BCL9 (0.66) | BCL9CTNNB1GAAPTPN7PTPN12 | |
| SCHEMBL9967879 | 0.81 | BCL9 (0.70) | BCL9CTNNB1GAAPTPN7PTPN12 | |
| SCHEMBL957930 | 0.81 | BCL9 (0.81) | BCL9CTNNB1GAAPTPN7PTPN12 | |
| SCHEMBL12687333 | 0.80 | BCL9 (0.60) | BCL9CTNNB1GAAPTPN7PTPN12 | |
| SCHEMBL13320022 | 0.80 | BCL9 (0.64) | BCL9CTNNB1GAAPTPN7PTPN12 | |
| SCHEMBL11718045 | 0.80 | BCL9 (0.68) | BCL9CTNNB1GAAPTPN7PTPN12 | |
| SCHEMBL3749119 | 0.80 | BCL9 (0.68) | BCL9CTNNB1GAAPTPN7PTPN12 | |
| SCHEMBL6819876 | 0.78 | HTR2A (0.53) | BCL9CTNNB1GAAPTPN7PTPN12 | |
| SCHEMBL734833 | 0.78 | GAA (0.56) | BCL9CTNNB1GAAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1230242-A1 | USE OF 9-SUBSTITUTED HYPOXANTHINE DERIVATIVES TO STIMULATE REGENERATION OF NERVOUS TISSUE | Neotherapeutics, Inc. (US) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001036419-A9 | USE OF 9-SUBSTITUTED HYPOXANTHINE DERIVATIVES TO STIMULATE REGENERATION OF NERVOUS TISSUE | NEOTHERAPEUTICS INC (US) | 2002-08-08 | — | — | WO | disclosed |
| US-6288069-B1 | Use of 9-substituted hypoxanthine derivatives to stimulate regeneration of nervous tissue | NEOTHERAPEUTICS, INC. | 2001-09-11 | — | — | US | disclosed |
| WO-2001036419-A1 | USE OF 9-SUBSTITUTED HYPOXANTHINE DERIVATIVES TO STIMULATE REGENERATION OF NERVOUS TISSUE | NEOTHERAPEUTICS, INC. (US) | 2001-05-25 | — | — | WO | disclosed |
| EP-0522082-B1 | MULTI-FUNCTIONAL PHARMACEUTICAL COMPOUNDS AND METHODS OF USE | GLASKY ALVIN J (US) | 1997-07-02 | — | — | EP | disclosed |
| EP-0522082-A4 | MULTI-FUNCTIONAL PHARMACEUTICAL COMPOUNDS AND METHODS OF USE | — | 1993-06-09 | — | — | EP | disclosed |
| EP-0522082-A1 | MULTI-FUNCTIONAL PHARMACEUTICAL COMPOUNDS AND METHODS OF USE. | GLASKY ALVIN J (US) | 1993-01-13 | — | — | EP | disclosed |
| US-5091432-A | Synergistic | SPECTRUM PHARMACEUTICALS, INC. | 1992-02-25 | — | — | US | disclosed |
| WO-1991014434-A1 | MULTI-FUNCTIONAL PHARMACEUTICAL COMPOUNDS AND METHODS OF USE | GLASKY ALVIN J (US) | 1991-10-03 | — | — | WO | disclosed |