Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hippuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.66 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | PTPRC | P08575 | 2/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.56 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22030672 | 0.98 | GAA (0.68) | MAPTKDM4EHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL7486 | 0.98 | GAA (0.68) | MAPTKDM4EHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL428479 | 0.98 | GAA (0.68) | MAPTKDM4EHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL8165809 | 0.96 | MAPT (0.66) | MAPTKDM4EHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL15416338 | 0.96 | MAPT (0.66) | MAPTKDM4EHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL11656206 | 0.96 | MAPT (0.66) | MAPTKDM4EHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL11709120 | 0.96 | MAPT (0.66) | MAPTKDM4EHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL21569381 | 0.96 | MAPT (0.66) | MAPTKDM4EHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL657588 | 0.96 | KDM4E (0.66) | MAPTKDM4EHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL3448563 | 0.96 | MAPT (0.66) | MAPTKDM4EHIF1ASLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240091195-A1 | MEDICINE COMPRISING GLYCOPYRRONIUM SALICYLATE | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 2024-03-21 | — | — | US | disclosed |
| EP-4289424-A1 | PHARMACEUTICAL COMPRISING GLYCOPYRRONIUM-SALICYLATE | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 2023-12-13 | — | — | EP | disclosed |
| CN-116887825-A | Medicine containing glycopyrronium salicylate | 株式会社三和化学研究所 | 2023-10-13 | — | — | CN | disclosed |
| WO-2022168940-A1 | PHARMACEUTICAL COMPRISING GLYCOPYRRONIUM-SALICYLATE | 株式会社 三和化学研究所 | 2022-08-11 | — | — | WO | disclosed |
| CN-110724065-B | Hippurate corrosion-resistant ionic liquid and preparation method and application thereof | 中国科学院兰州化学物理研究所 | 2022-04-08 | — | — | CN | disclosed |
| CN-110724065-A | Hippurate corrosion-resistant ionic liquid and preparation method and application thereof | 中国科学院兰州化学物理研究所 | 2020-01-24 | — | — | CN | disclosed |
| EP-0639195-B1 | 2-ACYLOXYCEPHEM DERIVATIVES AS ELASTASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 1999-05-26 | — | — | EP | disclosed |
| US-5587373-A | ELASTASE INHIBITORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1996-12-24 | — | — | US | disclosed |
| EP-0639195-A1 | 2-ACYLOXYCEPHEM DERIVATIVES AS ELASTASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-02-22 | — | — | EP | disclosed |
| WO-1994020504-A1 | 2-ACYLOXYCEPHEM DERIVATIVES AS ELASTASE INHIBITORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1994-09-15 | — | — | WO | disclosed |
| US-4258129-A | IMPROVE GREEN SHELF LIFE | FUJI PHOTO FILM CO., LTD. (JP) | 1981-03-24 | — | — | US | disclosed |
| US-4211839-A | SILVER HALIDE AND ORGANIC SILVER SALT PREPARED IN AN IMINO COMPOUND | FUJI PHOTO FILM CO., LTD. (JP) | 1980-07-08 | — | — | US | disclosed |
| US-4188212-A | BEZNOTRIAZOLE | FUJI PHOTO FILM CO., LTD. (JP) | 1980-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240091195-A1 | MEDICINE COMPRISING GLYCOPYRRONIUM SALICYLATE | NEU3, NEU4, ST6GAL1 | MAPT 3917/4885KDM4E 3068/4885HIF1A 4207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.